Fine specificity analysis of human influenza-specific cloned cell lines
Identifieur interne : 000316 ( France/Analysis ); précédent : 000315; suivant : 000317Fine specificity analysis of human influenza-specific cloned cell lines
Auteurs : Ghislaine Sterkers [France] ; Jean Michon [France] ; Yvette Henin [France] ; Elisabeth Gomard [France] ; Claude Hannoun [France] ; Jean Paul Lévy [France]Source :
- Cellular Immunology [ 0008-8749 ] ; 1985.
English descriptors
- Teeft :
- Antibody synthesis, Antigenic, Antigenic specificities, Antigenic specificity, Assay, Avian strains, Braciale, Cell line, Cell lines, Clone, Cotc2, Cotc2 cells, Cotc6, Cotc8, Culture medium, Cytolytic, Cytolytic activity, Determinant, Different donors, Different influenza virus strains, Different strains, Drw8 phenotype, Effector cells, Epitope, External components, Fine specificity analysis, Functional properties, Hemagglutinin, Hemagglutinin units, Human strains, Immunol, Infectious viruses, Influenza, Influenza strains, Influenza virus, Influenza viruses, Internal components, Large panel, Matrix protein, Neuraminidase, Peripheral blood, Proliferation assay, Proliferation assays, Proliferative response, Recombinant strain, Same pattern, Specific helper activity, Sterkers, Surface glycoproteins, Talo, Target cells, Triplicate cultures, Various numbers, Virus, Virus strain, Virus strains.
Abstract
Abstract: Influenza-specific human-T-cell clones, proliferating in the presence of virus-infected cells with restriction by class II molecules and displaying class II-restricted CTL activity or specific helper activity in antibody synthesis, have been analyzed for antigenic specificities. All of them were obtained by in vitro stimulation against influenza A/Texas virus. In all cases the virus specificity appeared identical in cytolytic and proliferative responses. Three of the clones were broadly cross-reactive, recognizing all or almost all type A influenza strains. The three remaining clones were subtype specific when tested with human strains and recognized the surface glycoproteins of influenza virus. One of these lines reacted with an epitope of the neuraminidase N2 while the other two recognized the hemagglutinin H3. By using a large panel of mammalian and avian influenza strains, it can be demonstrated that hemagglutinin-specific human T cells can recognize a cross-reacting determinant shared by H3 and H4 subtypes of hemagglutinin which has never been detected with antibodies.
Url:
DOI: 10.1016/0008-8749(85)90263-1
Affiliations:
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ISTEX:98B82D674AD4B78D1FC8A51F6F4CC87E6E947346Le document en format XML
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des Tumeurs, INSERM U 152, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75014, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Cellular Immunology</title><title level="j" type="abbrev">YCIMM</title><idno type="ISSN">0008-8749</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">94</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="394">394</biblScope><biblScope unit="page" to="405">405</biblScope></imprint><idno type="ISSN">0008-8749</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0008-8749</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody synthesis</term><term>Antigenic</term><term>Antigenic specificities</term><term>Antigenic 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By using a large panel of mammalian and avian influenza strains, it can be demonstrated that hemagglutinin-specific human T cells can recognize a cross-reacting determinant shared by H3 and H4 subtypes of hemagglutinin which has never been detected with antibodies.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Sterkers, Ghislaine" sort="Sterkers, Ghislaine" uniqKey="Sterkers G" first="Ghislaine" last="Sterkers">Ghislaine Sterkers</name></region><name sortKey="Gomard, Elisabeth" sort="Gomard, Elisabeth" uniqKey="Gomard E" first="Elisabeth" last="Gomard">Elisabeth Gomard</name><name sortKey="Hannoun, Claude" sort="Hannoun, Claude" uniqKey="Hannoun C" first="Claude" last="Hannoun">Claude Hannoun</name><name sortKey="Henin, Yvette" sort="Henin, Yvette" uniqKey="Henin Y" first="Yvette" last="Henin">Yvette Henin</name><name sortKey="Levy, Jean Paul" sort="Levy, Jean Paul" uniqKey="Levy J" first="Jean Paul" last="Lévy">Jean Paul Lévy</name><name sortKey="Michon, Jean" sort="Michon, Jean" uniqKey="Michon J" first="Jean" last="Michon">Jean Michon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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